Once the Biosketch or CPOS is complete, you have two options: you can view a draft version to be certain it looks right, or you can Certify and download.

The draft version will be watermarked as a draft. The draft cannot be submitted in a grant proposal. Delegates cannot certify for the PI. When the PI or other senior or key personnel is ready to certify, they can click Download PDF. It will prompt them to agree with the legally-binding certification statement. After certifying, the PDF will download. This should be uploaded without edits.
Some computer arrangements can make invisible changes to PDFs when viewing them. If you need to check the accuracy of the document, it is recommended that you do so with the View Draft function. Any changes made after downloading the certified PDF will affect its compatibility with the grants.gov / research.gov submission process.
If the personnel who owns the Biosketch/CPOS need to make edits or changes, they must make them in SciENcv and then re-certify and download a new copy.